Minimally invasive percutaneous ablation procedures with radiological image guidance are already an inherent part of modern multimodal tumor therapies. They can complementarily be used complementary to tumor surgery and systemic medicinal chemotherapy and also be performed repetitive and in principle also be on an outpatient basis with regard to the good patient tolerance and a high safety profile.
For local image-guided therapies of described tumors a variety of ablative procedures have been developed. These are based on the local application of energy or therapeutics. So interstitial brachytherapy is, for example, considered as a safe and effective ablation procedure in curative and palliative radiation oncology. Of great interest in this context is a prospective irradiation planning software, which provides suggestions for optimization regarding the number and location of the catheters during the intervention in real time on the basis of 3D data sets. The same applies to ablative processes which can destroy tissue through heat or pressure waves, and in which energy is applied with needles, probes or catheters. In the course of this a significant potential to reduce side effects and improve treatment outcomes in comparison to current phenomenological approaches lies within the use of dynamic mathematical models for treatment planning.
The integration of different imaging modalities for representing the planning data is will be jointly developed by the Faculty of Medicine and Faculty of Computer Science. Furthermore are experiences and results from the research center "Dynamical Systems-Biosystems Engineering" integrated in this project in relation to the mathematical modeling and analysis of biological processes. The Faculty of Computer Science at the Otto-von-Guericke University has proven expertise in the visualization of medical data.
Eröffnung
