Positron emission tomography (PET) detects the coincidence of positrons by its annihilation radiation, which are formed during the decay of the radioactive tracer with the electrons of the tissue. SPECT (single photon emission computed tomography) registered directly the emitted photons. The detectors allow the measurement of different diagnostic "tracer".
The measurement of the distribution pattern of yttrium-90, which is used therapeutically in the radio embolization, would allow direct imaging of the applied dose, however, is not yet carried out. Since yttrium-90 exposes to radiation of 99% with beta-decay, an adaptation of the nuclear medicine imaging is necessary.
The participants involved in the STIMULATE- project have many years of experience in the use and development of nuclear medicine procedures (PET and SPECT).
So far, the dose distribution is predicted for yttrium-90 therapy by prior imaging using an analog tracer with active SPECT or PET markers (e.g., technetium-99). Combining both in one image framework during the radiotherapy would avoid the uncertainty of this prognosis.
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