Effects of Circulating HMGB-1 and Histones on Cardiomyocytes-Hemadsorption of These DAMPs as Therapeutic Strategy after Multiple Trauma

Weber, Birte; Lackner, Ina; Baur, Meike; Fois, Giorgio; Gebhard, Florian; Marzi, Ingo; Schrezenmeier, Hubert; Relja, Borna; Kalbitz, Miriam

doi:10.3390/jcm9051421

by Birte Weber, Ina Lackner, Meike Baur, Giorgio Fois, Florian Gebhard, Ingo Marzi, Hubert Schrezenmeier, Borna Relja, Miriam Kalbitz

Abstract:

BACKGROUND AND PURPOSE: The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat CM dysfunction. EXPERIMENTAL APPROACH: We evaluated cell viability, calcium handling and mitochondrial respiration of human cardiomyocytes in the presence of

Reference:

Effects of Circulating HMGB-1 and Histones on Cardiomyocytes-Hemadsorption of These DAMPs as Therapeutic Strategy after Multiple Trauma (Birte Weber, Ina Lackner, Meike Baur, Giorgio Fois, Florian Gebhard, Ingo Marzi, Hubert Schrezenmeier, Borna Relja, Miriam Kalbitz), In Journal of clinical medicine, volume 9, 2020.

Bibtex Entry:

@article{weber_effects_2020,
	title = {Effects of {Circulating} {HMGB}-1 and {Histones} on {Cardiomyocytes}-{Hemadsorption} of {These}  {DAMPs} as {Therapeutic} {Strategy} after {Multiple} {Trauma}},
	volume = {9},
	issn = {2077-0383 2077-0383 2077-0383},
	doi = {10.3390/jcm9051421},
	abstract = {BACKGROUND AND PURPOSE: The aim of the study was to determine the effects of  post-traumatically released High Mobility Group Box-1 protein (HMGB1) and  extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic  option to capture circulating histones after trauma, using a hemadsorption filter to  treat CM dysfunction. EXPERIMENTAL APPROACH: We evaluated cell viability, calcium  handling and mitochondrial respiration of human cardiomyocytes in the presence of},
	language = {eng},
	number = {5},
	journal = {Journal of clinical medicine},
	author = {Weber, Birte and Lackner, Ina and Baur, Meike and Fois, Giorgio and Gebhard, Florian and Marzi, Ingo and Schrezenmeier, Hubert and Relja, Borna and Kalbitz, Miriam},
	month = may,
	year = {2020},
	pmid = {32403440},
	pmcid = {PMC7291040},
	keywords = {calcium handling, early myocardial damage (EMD), DAMPs, hemadsorption, mitochondrial dysfunction, post-traumatic}
}