Curcumin-A Viable Agent for Better Bladder Cancer Treatment

Rutz, Jochen; Janicova, Andrea; Woidacki, Katja; Chun, Felix K.-H.; Blaheta, Roman A.; Relja, Borna

doi:10.3390/ijms21113761

by Jochen Rutz, Andrea Janicova, Katja Woidacki, Felix K.-H. Chun, Roman A. Blaheta, Borna Relja

Abstract:

Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One of these is curcumin, the principal component of Curcuma longa that has shown chemopreventive effects in experimental cancer models. Clinical and preclinical studies point to its role as a chemosensitizer, and it has been shown to protect organs from toxicity induced by chemotherapy. These properties indicate that curcumin could hold promise as a candidate for additive cancer treatment. This review evaluates the relevance of curcumin as an integral part of therapy for bladder cancer.

Reference:

Curcumin-A Viable Agent for Better Bladder Cancer Treatment (Jochen Rutz, Andrea Janicova, Katja Woidacki, Felix K.-H. Chun, Roman A. Blaheta, Borna Relja), In International journal of molecular sciences, volume 21, 2020.

Bibtex Entry:

@article{rutz_curcumin-viable_2020,
	title = {Curcumin-{A} {Viable} {Agent} for {Better} {Bladder} {Cancer} {Treatment}},
	volume = {21},
	issn = {1422-0067 1422-0067},
	doi = {10.3390/ijms21113761},
	abstract = {Although the therapeutic armamentarium for bladder cancer has considerably widened  in the last few years, severe side effects and the development of resistance hamper  long-term treatment success. Thus, patients turn to natural plant products as  alternative or complementary therapeutic options. One of these is curcumin, the  principal component of Curcuma longa that has shown chemopreventive effects in  experimental cancer models. Clinical and preclinical studies point to its role as a  chemosensitizer, and it has been shown to protect organs from toxicity induced by  chemotherapy. These properties indicate that curcumin could hold promise as a  candidate for additive cancer treatment. This review evaluates the relevance of  curcumin as an integral part of therapy for bladder cancer.},
	language = {eng},
	number = {11},
	journal = {International journal of molecular sciences},
	author = {Rutz, Jochen and Janicova, Andrea and Woidacki, Katja and Chun, Felix K.-H. and Blaheta, Roman A. and Relja, Borna},
	month = may,
	year = {2020},
	pmid = {32466578},
	pmcid = {PMC7312715},
	keywords = {*Antineoplastic Combined Chemotherapy Protocols, Animals, Antineoplastic Agents, Phytogenic/administration \& dosage/*therapeutic use, BCG Vaccine/administration \& dosage/therapeutic use, bioavailability, bladder cancer, chemoprotection, chemoresistance, curcumin, Curcumin/administration \& dosage/*therapeutic use, Humans, Urinary Bladder Neoplasms/*drug therapy}
}