Different experimental multiple trauma models induce comparable inflammation and organ injury

Relja, Borna; Yang, Bing; Bundkirchen, Katrin; Xu, Baolin; Köhler, Kernt; Neunaber, Claudia

doi:10.1038/s41598-020-76499-z

by Borna Relja, Bing Yang, Katrin Bundkirchen, Baolin Xu, Kernt Köhler, Claudia Neunaber

Abstract:

Multiple injuries appear to be a decisive factor for experimental polytrauma. Therefore, our aim was to compare the inflammatory response and organ damage of five different monotrauma with three multiple trauma models. For this, mice were randomly assigned to 10 groups: Healthy control (Ctrl), Sham, hemorrhagic shock (HS), thoracic trauma (TxT), osteotomy with external fixation (Fx), bilateral soft tissue trauma (bsTT) or laparotomy (Lap); polytrauma I (PT I, TxT + HS + Fx), PT II (TxT + HS + Fx + Lap) and one multi-trauma group (MT, TxT + HS + bsTT + Lap). The inflammatory response and organ damage were quantified at 6 h by analyses of IL-6,

Reference:

Different experimental multiple trauma models induce comparable inflammation and organ injury (Borna Relja, Bing Yang, Katrin Bundkirchen, Baolin Xu, Kernt Köhler, Claudia Neunaber), In Scientific reports, volume 10, 2020.

Bibtex Entry:

@article{relja_different_2020,
	title = {Different experimental multiple trauma models induce comparable inflammation and  organ injury},
	volume = {10},
	issn = {2045-2322 2045-2322},
	doi = {10.1038/s41598-020-76499-z},
	abstract = {Multiple injuries appear to be a decisive factor for experimental polytrauma.  Therefore, our aim was to compare the inflammatory response and organ damage of five  different monotrauma with three multiple trauma models. For this, mice were randomly  assigned to 10 groups: Healthy control (Ctrl), Sham, hemorrhagic shock (HS),  thoracic trauma (TxT), osteotomy with external fixation (Fx), bilateral soft tissue  trauma (bsTT) or laparotomy (Lap); polytrauma I (PT I, TxT + HS + Fx), PT II  (TxT + HS + Fx + Lap) and one multi-trauma group (MT, TxT + HS + bsTT + Lap). The  inflammatory response and organ damage were quantified at 6 h by analyses of IL-6,},
	language = {eng},
	number = {1},
	journal = {Scientific reports},
	author = {Relja, Borna and Yang, Bing and Bundkirchen, Katrin and Xu, Baolin and Köhler, Kernt and Neunaber, Claudia},
	month = nov,
	year = {2020},
	pmid = {33214576},
	pmcid = {PMC7678855},
	pages = {20185}
}