by Mohamed Zakaria Nassef, Daniela Melnik, Sascha Kopp, Jayashree Sahana, Manfred Infanger, Ronald Lützenberg, Borna Relja, Markus Wehland, Daniela Grimm, Marcus Krüger
Abstract:
Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an "unsolved problem of the last century", breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology.
Reference:
Breast Cancer Cells in Microgravity: New Aspects for Cancer Research (Mohamed Zakaria Nassef, Daniela Melnik, Sascha Kopp, Jayashree Sahana, Manfred Infanger, Ronald Lützenberg, Borna Relja, Markus Wehland, Daniela Grimm, Marcus Krüger), In International journal of molecular sciences, volume 21, 2020.
Bibtex Entry:
@article{nassef_breast_2020,
title = {Breast {Cancer} {Cells} in {Microgravity}: {New} {Aspects} for {Cancer} {Research}},
volume = {21},
issn = {1422-0067 1422-0067},
doi = {10.3390/ijms21197345},
abstract = {Breast cancer is the leading cause of cancer death in females. The incidence has risen dramatically during recent decades. Dismissed as an "unsolved problem of the last century", breast cancer still represents a health burden with no effective solution identified so far. Microgravity (µg) research might be an unusual method to combat the disease, but cancer biologists decided to harness the power of µg as an exceptional method to increase efficacy and precision of future breast cancer therapies. Numerous studies have indicated that µg has a great impact on cancer cells; by influencing proliferation, survival, and migration, it shifts breast cancer cells toward a less aggressive phenotype. In addition, through the de novo generation of tumor spheroids, µg research provides a reliable in vitro 3D tumor model for preclinical cancer drug development and to study various processes of cancer progression. In summary, µg has become an important tool in understanding and influencing breast cancer biology.},
language = {eng},
number = {19},
journal = {International journal of molecular sciences},
author = {Nassef, Mohamed Zakaria and Melnik, Daniela and Kopp, Sascha and Sahana, Jayashree and Infanger, Manfred and Lützenberg, Ronald and Relja, Borna and Wehland, Markus and Grimm, Daniela and Krüger, Marcus},
month = oct,
year = {2020},
pmid = {33027908},
pmcid = {PMC7582256},
keywords = {*Weightlessness, Apoptosis, Breast Neoplasms/pathology/*therapy, cancer therapeutic targets, cell adhesion, Cell Movement/*radiation effects, Cell Proliferation/*radiation effects, Cell Survival/radiation effects, cytoskeleton, Female, Humans, in vitro 3D tumor model, metastasis, proliferation, Spheroids, Cellular/radiation effects}
}