by Philipp Berg, Samuel Vos, Mathias Becker, Steffen Serowy, Thomas Redel, Gabor Janiga, Martin Skalej, Oliver Beuing
Abstract:
Computational Fluid Dynamics enables the investigation of patient-specific hemodynamics for rupture predictions and treatment support of intracranial aneurysms. However, due to numerous simplifications to decrease the computations effort, clinical applicability is limited until now. To overcome this situation a clinical research software prototype was tested that can be easily operated by attending physicians. In order to evaluate the accuracy of this prototype, four patient-specific intracranial aneurysms were investigated using four different spatial resolutions. The results demonstrate that physicians were able to generate hemodynamic predictions within several minutes at low spatial resolution. However, depending on the parameter of interest and the desired accuracy, higher resolutions are required, which will lead to an increase of computational times that still look very attractive towards clinical usability. The study shows that the next step towards an applicable individualized therapy for patients harboring intracranial aneurysms can be done. However, further in vivo validations are required to guarantee realistic predictions in future studies.
Reference:
Bringing hemodynamic simulations closer to the clinics: a CFD prototype study for intracranial aneurysms. (Philipp Berg, Samuel Vos, Mathias Becker, Steffen Serowy, Thomas Redel, Gabor Janiga, Martin Skalej, Oliver Beuing), In Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, volume 2016, 2016.
Bibtex Entry:
@article{berg_bringing_2016,
	title = {Bringing hemodynamic simulations closer to the clinics: a {CFD} prototype study for intracranial aneurysms.},
	volume = {2016},
	issn = {1557-170X 1557-170X},
	doi = {10.1109/EMBC.2016.7591434},
	abstract = {Computational Fluid Dynamics enables the investigation of patient-specific hemodynamics for rupture predictions and treatment support of intracranial aneurysms. However, due to numerous simplifications to decrease the computations effort, clinical applicability is limited until now. To overcome this situation a clinical research software prototype was tested that can be easily operated by attending physicians. In order to evaluate the accuracy of this prototype, four patient-specific intracranial aneurysms were investigated using four different spatial resolutions. The results demonstrate that physicians were able to generate hemodynamic predictions within several minutes at low spatial resolution. However, depending on the parameter of interest and the desired accuracy, higher resolutions are required, which will lead to an increase of computational times that still look very attractive towards clinical usability. The study shows that the next step towards an applicable individualized therapy for patients harboring intracranial aneurysms can be done. However, further in vivo validations are required to guarantee realistic predictions in future studies.},
	language = {eng},
	journal = {Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference},
	author = {Berg, Philipp and Vos, Samuel and Becker, Mathias and Serowy, Steffen and Redel, Thomas and Janiga, Gabor and Skalej, Martin and Beuing, Oliver},
	month = aug,
	year = {2016},
	pmid = {28269011},
	keywords = {*Computer Simulation, *Hemodynamics, *Hydrodynamics, Adult, Female, Humans, Intracranial Aneurysm/*physiopathology, Male, Middle Aged, Reproducibility of Results},
	pages = {3302--3305}
}