@article{sindeev_phase-contrast_2018,
	title = {Phase-contrast {MRI} versus numerical simulation to quantify hemodynamical changes in cerebral aneurysms after flow diverter treatment.},
	volume = {13},
	issn = {1932-6203 1932-6203},
	doi = {10.1371/journal.pone.0190696},
	abstract = {Cerebral aneurysms are a major risk factor for intracranial bleeding with devastating consequences for the patient. One recently established treatment is the implantation of flow-diverters (FD). Methods to predict their treatment success before or directly after implantation are not well investigated yet. The aim of this work was to quantitatively study hemodynamic parameters in patient-specific models of treated cerebral aneurysms and its correlation with the clinical outcome. Hemodynamics were evaluated using both computational fluid dynamics (CFD) and phase contrast (PC) MRI. CFD simulations and in vitro MRI measurements were done under similar flow conditions and results of both methods were comparatively analyzed. For preoperative and postoperative distribution of hemodynamic parameters, CFD simulations and PC-MRI velocity measurements showed similar results. In both cases where no occlusion of the aneurysm was observed after six months, a flow reduction of about 30-50\% was found, while in the clinically successful case with complete occlusion of the aneurysm after 6 months, the flow reduction was about 80\%. No vortex was observed in any of the three models after treatment. The results are in agreement with recent studies suggesting that CFD simulations can predict post-treatment aneurysm flow alteration already before implantation of a FD and PC-MRI could validate the predicted hemodynamic changes right after implantation of a FD.},
	language = {eng},
	number = {1},
	journal = {PloS one},
	author = {Sindeev, Sergey and Arnold, Philipp Georg and Frolov, Sergey and Prothmann, Sascha and Liepsch, Dieter and Balasso, Andrea and Berg, Philipp and Kaczmarz, Stephan and Kirschke, Jan Stefan},
	year = {2018},
	pmid = {29304062},
	pmcid = {PMC5755883},
	keywords = {*Cerebrovascular Circulation/physiology, *Magnetic Resonance Imaging/instrumentation/methods, *Models, *Patient-Specific Modeling, Adult, Anatomic, Blood Flow Velocity, Female, Humans, Imaging, Intracranial Aneurysm/diagnostic imaging/*physiopathology/*surgery, Male, Middle Aged, Models, Neurological, Phantoms, Printing, Silicones, Three-Dimensional, Treatment Outcome},
	pages = {e0190696}
}