by Oliver Beuing, Axel Boese, Yiannis Kyriakou, Yu Deuerling-Zengh, Boris Jöllenbeck, Cordula Scherlach, Angelika Lenz, Steffen Serowy, Sebastian Gugel, Georg Rose, Martin Skalej
Abstract:
BACKGROUND AND PURPOSE: Endovascular therapy is an emerging treatment option in patients with acute ischemic stroke and especially in cases presenting late after symptom onset. Information about remaining viable tissue as measured with perfusion imaging is crucial for proper patient selection. The aim of this study was to investigate whether perfusion imaging with C-arm CT in the angiography suite is feasible and provides measurements comparable with ones made by CTP. MATERIALS AND METHODS: The MCA was occluded surgically in 6 sheep. Perfusion studies were performed before surgery, immediately after, and at 3 hours after MCA occlusion by using a robotic flat panel detector C-arm angiographic system. For comparison, conventional CTP was performed at the same time points. Two different protocols with the C-arm CT were tested. Images were analyzed by 2 readers with regard to the presence and size of perfusion abnormalities. RESULTS: With C-arm CT, perfusion abnormalities were detected with a high sensitivity and specificity when vessel occlusion was confirmed by criterion standard DSA. No difference was found between lesions sizes measured with the 2 C-arm CT protocols and CTP. Growth of the CBV lesions with time was captured with C-arm CT and CTP. CONCLUSIONS: In this small study, it was feasible to qualitatively measure CBV and CBF by using a flat panel detector angiographic system.
Reference:
A novel technique for the measurement of CBF and CBV with robot-arm-mounted flat panel CT in a large-animal model. (Oliver Beuing, Axel Boese, Yiannis Kyriakou, Yu Deuerling-Zengh, Boris Jöllenbeck, Cordula Scherlach, Angelika Lenz, Steffen Serowy, Sebastian Gugel, Georg Rose, Martin Skalej), In AJNR. American journal of neuroradiology, volume 35, 2014.
Bibtex Entry:
@article{beuing_novel_2014,
	title = {A novel technique for the measurement of {CBF} and {CBV} with robot-arm-mounted flat panel {CT} in a large-animal model.},
	volume = {35},
	copyright = {(c) 2014 by American Journal of Neuroradiology.},
	issn = {1936-959X 0195-6108},
	doi = {10.3174/ajnr.A3973},
	abstract = {BACKGROUND AND PURPOSE: Endovascular therapy is an emerging treatment option in patients with acute ischemic stroke and especially in cases presenting late after symptom onset. Information about remaining viable tissue as measured with perfusion imaging is crucial for proper patient selection. The aim of this study was to investigate whether perfusion imaging with C-arm CT in the angiography suite is feasible and provides measurements comparable with ones made by CTP. MATERIALS AND METHODS: The MCA was occluded surgically in 6 sheep. Perfusion studies were performed before surgery, immediately after, and at 3 hours after MCA occlusion by using a robotic flat panel detector C-arm angiographic system. For comparison, conventional CTP was performed at the same time points. Two different protocols with the C-arm CT were tested. Images were analyzed by 2 readers with regard to the presence and size of perfusion abnormalities. RESULTS: With C-arm CT, perfusion abnormalities were detected with a high sensitivity and specificity when vessel occlusion was confirmed by criterion standard DSA. No difference was found between lesions sizes measured with the 2 C-arm CT protocols and CTP. Growth of the CBV lesions with time was captured with C-arm CT and CTP. CONCLUSIONS: In this small study, it was feasible to qualitatively measure CBV and CBF by using a flat panel detector angiographic system.},
	language = {eng},
	number = {9},
	journal = {AJNR. American journal of neuroradiology},
	author = {Beuing, Oliver and Boese, Axel and Kyriakou, Yiannis and Deuerling-Zengh, Yu and Jöllenbeck, Boris and Scherlach, Cordula and Lenz, Angelika and Serowy, Steffen and Gugel, Sebastian and Rose, Georg and Skalej, Martin},
	month = sep,
	year = {2014},
	pmid = {24831590},
	keywords = {Animal, Animals, Cerebral Angiography/*methods, Cerebrovascular Circulation/*physiology, Disease Models, Infarction, Middle Cerebral Artery/diagnostic imaging, Perfusion Imaging/*methods, Robotics/*methods, Sheep, Stroke/*diagnostic imaging},
	pages = {1740--1745}
}